The Museum in Arcadia hosts many collections including the following:
- Historic Photos
- Historic Maps
- Newspapers (on microfilm)
- Arcadia New-Leader (1875-1955)
- Arcadian (1895-1907)
- Bound Newspapers
- Arcadia High School Yearbooks
- History of Trempealeau County (1917)
- History of Buffalo County (1919)
- Jerome Bohr Novels (Complete Collection)
- Krumholz Handwritten Journals
- An Eclectic Collection of Memorability
- The Witness Tree
- Lou Erickson Sauer Collection
- Ernie Reck Memorability
- Arcadia Brewery Collection
- Cemetary Records
- Rural School Histories